Pancreatic Polypeptide

GI / Appetite Regulation

Also known as: PP, PPY

PP-Fold FamilyResearch phase: Preclinical / Clinical researchRegulatory: Not approved as drug. Endogenous hormone. Research interest for obesity.

Mechanism

Pancreatic polypeptide (PP) is a gut hormone released after meals that reduces appetite and slows digestion. Low PP levels have been associated with obesity.

Technical detail

Pancreatic polypeptide is a 36-amino acid peptide secreted by PP cells in pancreatic islets in response to food intake, vagal stimulation, and CCK. It activates Y4 receptors (NPY4R) to reduce food intake, slow gastric emptying, and decrease pancreatic exocrine secretion. PP infusion reduces appetite in both lean and obese subjects.

Evidence

  • Low-dose pancreatic polypeptide inhibits food intake in man

    Jesudason DR et al. (2007) — Br J Nutr — PMID: 17313701

    In 14 lean fasted volunteers, low-dose pancreatic polypeptide infusion reduced buffet-meal energy intake by about 11% versus saline and lowered preprandial hunger, supporting a human satiety signal but only from acute infusion data.

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