Neuropeptide W
Neuromodulation / FeedingAlso known as: NPW, NPW-23, NPW-30
NeuropeptidesResearch phase: PreclinicalRegulatory: Not approved. Endogenous neuropeptide.
Mechanism
Neuropeptide W is a brain peptide involved in feeding, energy balance, pain, and neuroendocrine regulation. It signals through the same receptors as neuropeptide B.
Technical detail
Neuropeptide W exists as 23- and 30-amino acid forms, both activated by NPBWR1 (GPR7) and NPBWR2 (GPR8). Expressed in hypothalamus, it modulates feeding behavior, energy homeostasis, HPA axis activity, and inflammatory pain. NPW stimulates cortisol and prolactin secretion and may serve as a stress-responsive neuromodulator.