Neuropeptide B
Neuromodulation / PainAlso known as: NPB, NPB-23, NPB-29
NeuropeptidesResearch phase: PreclinicalRegulatory: Not approved. Endogenous neuropeptide.
Mechanism
Neuropeptide B is a brain peptide involved in pain signaling, feeding regulation, and neuroendocrine control. It shares receptors with neuropeptide W.
Technical detail
Neuropeptide B exists as 23- and 29-amino acid forms with a unique N-terminal brominated tryptophan modification. It signals via NPBWR1 and NPBWR2 (shared with NPW). Functions include modulation of inflammatory and neuropathic pain, feeding behavior, HPA axis regulation, and adipocyte differentiation. The bromine modification is rare among mammalian peptides.