Neuromedin U
Metabolic / NeuromodulationAlso known as: NMU, NmU-25
Neuromedin FamilyResearch phase: PreclinicalRegulatory: Not approved. Research peptide with therapeutic interest for obesity.
Mechanism
Neuromedin U is a neuropeptide involved in energy balance, feeding, and inflammation. It reduces food intake and increases energy expenditure, making it a target for obesity research.
Technical detail
Neuromedin U (NmU-25) is a 25-amino acid neuropeptide signaling through NMUR1 (peripheral, GI) and NMUR2 (CNS, hypothalamus). It suppresses food intake, increases locomotor activity and energy expenditure, stimulates CRH release, and activates type 2 innate lymphoid cells (ILC2s) in allergic inflammation. Long-acting NMU analogs are being explored for obesity.