HBD-3
Antimicrobial Peptide / Innate ImmunityAlso known as: Human Beta-Defensin 3, Beta-Defensin 3, DEFB103A, hBD-3
Beta-DefensinsResearch phase: PreclinicalRegulatory: Not approved as drug. Endogenous antimicrobial peptide.
Mechanism
HBD-3 is the most potent human beta-defensin, with strong activity against both gram-positive and gram-negative bacteria as well as fungi, even in salt concentrations that inactivate other defensins.
Technical detail
HBD-3 is a 45-amino acid inducible beta-defensin with broad-spectrum microbicidal activity at physiological salt concentrations, unlike HBD-1 and HBD-2. It kills MRSA and VRE through membrane disruption and also inhibits HIV-1 by directly interacting with virions and by upregulating APOBEC3A. Expression is induced by bacteria, TNF-α, and IFN-γ.