Dynorphin B
Opioid / NeuromodulationAlso known as: Dynorphin B, Rimorphin, Dyn B
Endogenous Opioid PeptidesResearch phase: PreclinicalRegulatory: Not approved. Endogenous peptide used in research only.
Mechanism
Dynorphin B is a natural opioid peptide that primarily activates kappa-opioid receptors, involved in stress responses and mood regulation rather than classical pain relief.
Technical detail
Dynorphin B (rimorphin) is a 13-amino acid peptide derived from prodynorphin. It is a preferential kappa-opioid receptor (KOR) agonist involved in stress-induced analgesia, dysphoria, and neuroendocrine regulation. KOR activation opposes dopaminergic reward pathways.