Cobratide

Venom-Derived / Analgesic

Also known as: Cobrotoxin, Ketongning

Snake Venom PeptidesResearch phase: Approved (China)Regulatory: Approved in China for chronic pain. Not approved by FDA or EMA.

Mechanism

Cobratide is a purified cobra neurotoxin approved in China as an analgesic for chronic pain conditions. It is one of the few venom-derived peptides in clinical use.

Technical detail

Cobratide is a short-chain alpha-neurotoxin (~7 kDa) from Naja atra venom that antagonizes muscle-type nicotinic acetylcholine receptors. Approved in China (intramuscular injection) for neuralgia, cancer pain, and rheumatoid arthritis pain. Analgesic mechanism involves cholinergic modulation and anti-inflammatory effects distinct from opioid pathways.

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