Anserine
Nutraceutical / AntioxidantAlso known as: Beta-Alanyl-1-Methylhistidine, β-Alanyl-N(π)-Methylhistidine
Mechanism
Anserine is a dipeptide related to carnosine, found in bird and fish muscle. It has antioxidant and anti-glycation properties with some evidence for uric acid reduction.
Technical detail
Anserine (β-alanyl-1-methylhistidine) is a methylated analog of carnosine abundant in avian and fish skeletal muscle. It scavenges reactive oxygen species and reactive carbonyl species, inhibits protein glycation, and has pH-buffering capacity. Clinical studies in Japan demonstrated uric acid-lowering effects in hyperuricemic subjects.
Evidence
- moderate
Effects of Anserine/Carnosine Supplementation on Mild Cognitive Impairment with APOE4.
Masuoka N et al. (2019) — Nutrients — PMID: 31319510
In a 12-week double-blind placebo-controlled trial of 54 subjects with MCI, anserine/carnosine improved global CDR versus placebo and showed subgroup benefit in APOE4-positive participants on gloCDR and MMSE.
- moderate
Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly People.
Hisatsune T et al. (2016) — Journal of Alzheimer's Disease — PMID: 26682691
Double-blind randomized trial in healthy older adults found 3 months of anserine/carnosine supplementation preserved delayed recall verbal memory versus placebo and was associated with lower inflammatory cytokines and preserved posterior cingulate perfusion.