Angiotensin III
Cardiovascular / EndocrineAlso known as: Ang III, Angiotensin(2-8), Des-Asp1-Angiotensin II
Renin-Angiotensin SystemResearch phase: PreclinicalRegulatory: Not approved as drug. Endogenous RAS peptide.
Mechanism
Angiotensin III is a breakdown product of angiotensin II that is a major stimulator of aldosterone release from the adrenal glands, contributing to sodium retention and blood pressure regulation.
Technical detail
Angiotensin III [Ang(2-8)] is a heptapeptide formed by aminopeptidase A cleavage of Ang II. It is the primary effector of aldosterone secretion in the zona glomerulosa, acting via AT1 receptors. It also stimulates vasopressin release centrally. Angiotensin III has ~40% of the vasopressor activity of Ang II but is equipotent for aldosterone stimulation.