Alpha-Conotoxin GI
Venom Peptide / NeuromuscularAlso known as: α-Conotoxin GI, Conotoxin GI
ConotoxinsResearch phase: Preclinical (research tool)Regulatory: Not approved. Research tool compound.
Mechanism
Alpha-conotoxin GI is a cone snail venom peptide that blocks nicotinic acetylcholine receptors at the neuromuscular junction, causing paralysis in prey.
Technical detail
α-Conotoxin GI is a 13-amino acid disulfide-rich peptide from Conus geographus that competitively antagonizes muscle-type nicotinic acetylcholine receptors (nAChRs) at the alpha/delta subunit interface. It is a key pharmacological tool for studying neuromuscular junction physiology.