Alamandine
Cardiovascular / ProtectiveAlso known as: Ala1-Ang(1-7)
Renin-Angiotensin SystemResearch phase: PreclinicalRegulatory: Not approved. Endogenous RAS peptide. Recently described (2013).
Mechanism
Alamandine is a recently discovered RAS peptide similar to angiotensin-(1-7) that causes blood vessel relaxation and has cardioprotective effects through the MrgD receptor.
Technical detail
Alamandine [Ala1-Ang(1-7)] is formed by decarboxylation of Ang-(1-7) aspartate to alanine, or by ACE2 cleavage of Ang A. It activates the Mas-related G-protein coupled receptor D (MrgD), producing vasodilation via NO release, anti-fibrotic effects, and anti-hypertensive actions. It represents a protective arm of the RAS complementary to the ACE2/Ang(1-7)/Mas axis.