AgRP

Neuromodulation / Appetite

Also known as: Agouti-Related Peptide, Agouti-Related Protein, AGRP

NeuropeptidesResearch phase: PreclinicalRegulatory: Not approved as drug. Endogenous neuropeptide. MC4R system is drug target for obesity.

Mechanism

AgRP is a potent appetite-stimulating peptide from the hypothalamus that blocks melanocortin receptors. It is one of the brain's strongest hunger signals and plays a central role in obesity research.

Technical detail

Agouti-related peptide (AgRP) is a 132-amino acid protein (active fragment: AgRP 83-132) expressed exclusively in arcuate nucleus AgRP/NPY neurons. It is an endogenous antagonist/inverse agonist at MC3R and MC4R, blocking α-MSH's anorexigenic signaling. AgRP neuron activation produces voracious feeding. It also has long-lasting effects through synaptic plasticity modulation. AgRP neurons are a major target for GLP-1 receptor agonist-mediated weight loss.

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