Intranasal delivery exploits the nasal mucosa for drug absorption via two pathways: (1) Systemic absorption through the respiratory epithelium into nasal blood vessels, and (2) Direct nose-to-brain transport via the olfactory nerve and trigeminal nerve pathways, bypassing the blood-brain barrier. This makes intranasal the preferred route for CNS-targeting peptides. TECHNIQUE: (1) Blow nose gently to clear mucus. (2) Prime the spray bottle (2-3 actuations until mist appears) if using for the first time. (3) Tilt head slightly forward (not back — tilting back sends the spray to the throat, not the nasal mucosa). (4) Insert tip ~1cm into nostril, angling slightly toward the outer wall of the nose (toward the ear, not the septum). (5) Spray while inhaling gently through the nose. (6) Hold breath for 5-10 seconds. (7) Alternate nostrils if multiple sprays are needed. COMMON PEPTIDES FOR INTRANASAL: Semax, NA-Semax Amidate, Selank, NA-Selank Amidate, Adamax, Oxytocin, BPC-157 (for nasal/sinus applications), glutathione (nasal). ABSORPTION: Bioavailability varies by peptide — typically 5-50% for intranasal vs. ~100% for injection. However, for CNS-targeted peptides, brain concentrations can be higher via intranasal than injection despite lower overall bioavailability.
injection
Intranasal Administration
💡 Tips
Do NOT use intranasal peptides when you have a cold, sinus infection, or significant nasal congestion — absorption will be poor and unpredictable. Do not snort forcefully — gentle inhalation is sufficient and prevents the spray from bypassing the nasal mucosa and going to the throat. If using multiple nasal peptides, wait 5-10 minutes between them. Store nasal spray peptides refrigerated and use within the timeframe specified (usually 30-60 days). If your nasal spray bottle clogs, run warm water over the nozzle — do not use a pin which could contaminate the bottle.
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