CYCLING RATIONALE: Cycling (periods of use followed by periods of rest) serves several purposes depending on the compound: (1) RECEPTOR DESENSITIZATION — GH secretagogue receptors (GHS-R1a) can downregulate with continuous stimulation. GHRPs (GHRP-2, GHRP-6, Hexarelin) are most prone to desensitization — Hexarelin being the worst offender. Ipamorelin is less prone but still benefits from cycling. CJC-1295 (GHRH analog) does not desensitize the same way. Standard protocol: 8-12 weeks on, 4 weeks off, or 5 days on / 2 days off within cycles. (2) HORMONAL AXIS RECOVERY — SARMs and other androgen-affecting compounds suppress the HPG axis (LH, FSH, testosterone). PCT (typically Clomid 25-50mg/day or Nolvadex 20mg/day for 4-6 weeks) is required after SARM cycles to restore endogenous testosterone production. (3) BIOREGULATOR PARADIGM — Khavinson bioregulators are designed for short courses (10-30 days) that "reprogram" cellular gene expression with lasting effects persisting 3-6 months. Continuous use is not recommended and may reduce efficacy. (4) NO CYCLING NEEDED — BPC-157, TB-500 (use until healed), GLP-1 agonists (continuous for metabolic management), melanocortin peptides (use as needed), most nootropic peptides (though some users benefit from periodic breaks to maintain sensitivity).
dosing
Cycling & Protocol Duration — How Long to Run Peptides
💡 Tips
SIGNS OF DESENSITIZATION: Diminishing effects despite consistent dosing — less GH release, reduced appetite suppression, weaker response. If you notice this, take a break. The receptors typically recover in 2-4 weeks. DO NOT increase the dose to chase diminishing effects — this worsens desensitization. SARM PCT IS NOT OPTIONAL: If you suppress your testosterone with SARMs and do not do PCT, recovery can take months and you risk prolonged hypogonadal symptoms (fatigue, depression, muscle loss, low libido). Get bloodwork before and after any SARM cycle.
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