Fat Loss / Weight Loss

Key considerations

• GLP-1 agonists like semaglutide and tirzepatide can cause significant appetite suppression — start at the lowest dose and titrate slowly
• Nausea and GI side effects are common during the first 4-6 weeks; eating smaller meals and staying hydrated helps
• Muscle loss is a real risk with rapid weight loss — prioritize protein intake (1g per pound of goal body weight) and resistance training
• Tesamorelin specifically targets visceral fat and is the only peptide FDA-approved for lipodystrophy-related fat reduction
• Retatrutide is a triple-agonist (GLP-1/GIP/glucagon) and represents the most aggressive pharmacological fat loss approach available

Basic tier — start here

• Semaglutide
• Liraglutide

Intermediate tier

• Semaglutide
• Tirzepatide
• Tesamorelin
• Liraglutide
• Exenatide
• Dulaglutide
• AOD 9604

Advanced tier

• Retatrutide
• Tirzepatide
• Tesamorelin
• MOTS-c
• Cagrilintide
• SLU-PP-332
• Survodutide
• Orforglipron
• AOD 9604
• HGH Fragment 176-191

Recommended stacks — basic

• Basic Fat Loss Stack
  basic tier
• The GLP-1 Starter Stack
  basic tier

Recommended stacks — intermediate

• Intermediate Fat Loss Stack
  intermediate tier

Recommended stacks — advanced

• Advanced Fat Loss Stack
  advanced tier
• The Next-Gen Weight Loss Stack
  advanced tier

Common questions

• How quickly will I lose weight on semaglutide?
• What is the difference between semaglutide, tirzepatide, and retatrutide?
• Will I regain weight if I stop taking GLP-1 peptides?
• Can I use GLP-1 agonists while building muscle?
• What dose should I start with for fat loss peptides?